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KMID : 0614619920240010111
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Korean Journal of Gastroenterology
1992 Volume.24 No. 1 p.111 ~ p.122
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comparative Study between Clonorchis sinensis-Positive and Clonorchis sinensis-Negative Cholangiocarcinoma
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Abstract
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There are several kinds of possible causes of cholangiocarcinoma. Clonorchiasis is an endemic disease in Korea and longstanding infection with Clonorchis sinensis is highly associated with cholangiocarcinoma in endemic area. but there are also
many
cases of cholangiocaricnoma which are not associated with Clonorchis sinensis. This study was retrospectively compared Clonorchis sinensispositive cholangiocarcinoma with Clonrchis sinensis-negative cholangiocarcinoma.
The author studied the differeces of clinical pictures. laboratory findings. location of the tumor and duration of survival between two groups (one group: 37 cases of C. s. positive cholangiocarcinoma, the other group: 36 cases of C. s. negative
cholangiocarcinoma).
@ES The results were as follws:
@EN 1) The mean age of both group was 62 years and male to female ratio was 2.1:1 and 2.6:1 respectively.
2) C. s. positive cholangiocarcinoma showe dhigh incidence in Kyongsang provinces and C. snegative cholangiocarcinoma in Pusan (p<0.01).
3) C. s. negative grou showed an increase in serum globulin level compared with C. s. positive group and the percentage of eosinophil was 10.6% in C. s. positive group and 4.6% in C. s. negative group (p<0.01).
4) The positive rate of Anti-HBc was 69% in C. s. positive group and 88% in C. s. negative group (p<0.01). This meant low rate of past infection with viral hepatitis B in C. s. positive group (p<0.01).
5) Most of the tumor was involved in extrahepatic bile duct. and upper 1/3 of extrahepatic bile duct was common location of C. s. positive and C. s. negative cholangiocarcinoma (65% vs 50%). C. s. negative group showed higher incidence of
location
in
distal portion of extrahepatic bile duct than C. s. positive group (p<0.01) (42% vs 21%).
6) The cases treated with surgical operation or PTBD# showed longer duration of survival than those of no specific treatment. But the difference between the two groups was not significant.
7) There was no difference of duration of survival according to tumor location between them in the patients treated with surgical operation or PTBD.
8) The microscopic finding of cholangiocarcinoma was tubular structure resembling adenocarcinoma and fibrous stroma. The microscopic finding of cholangiocarcinoma associated with clonor chiasis was adenomatous hyperplasia as a premalignant
lesion.
Clonorchis sinensis
# percutaneous transhepatic biliary drainage.
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